HMG1 — Saccharomyces cerevisiae S288c

Summary

YML075C (HMG1) encodes hydroxymethylglutaryl-CoA reductase (NADPH) activity and sterol sensor activity. The protein localises to the endoplasmic reticulum and nuclear membranes. In Saccharomyces cerevisiae, HMG1 is associated with the anabolism and catabolism of sterols, cholesterol, triterpenoids, quinones, phospholipids, and beta-carotene, as well as with membrane organisation, lipid and cholesterol homeostasis, spore germination, and response to wounding. The gene has been linked to traits including nickel and amino acid content and oxidative stress. Phenotypic associations include increased acid pH resistance, increased cell size and chronological lifespan, decreased vegetative growth and competitive fitness, and altered chemical compound accumulation. Studies of related genes in other fungi link the family to reduced virulence.