TDA9 — Saccharomyces cerevisiae S288c

Summary

YML081W in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with both activator and repressor activities, specific to RNA polymerase II, and contains a C2H2-type zinc finger domain. It is associated with responses to water, methanol, salt, and oleate, as well as regulation of carbon utilization, gluconeogenesis, and fatty acid oxidation. The gene is linked to cell wall thickening, negative regulation of flocculation, and positive regulation of cell-substrate adhesion and biofilm formation. It localizes to the nucleus, nucleoplasm, chromatin, heterochromatin, cytoplasm, and cytosol. Phenotypic associations include decreased anaerobic growth, increased invasive growth, decreased UV and hyperosmotic stress resistance, abnormal sporulation, and effects on chronological lifespan, competitive fitness, and vegetative growth rate. Studies of related genes in other species connect the family to carbon metabolism regulation.