RAD10 — Saccharomyces cerevisiae S288c

Summary

YML095C, also known as RAD10 in Saccharomyces cerevisiae S288c, encodes a protein with endonuclease activity that binds damaged DNA, single-stranded DNA, and polyubiquitin modification-dependent proteins. The protein localises to the nucleus, cytosol, the XPF-ERCC1 complex, and sites of double-strand breaks. YML095C is associated with multiple DNA repair pathways including nucleotide excision repair, mismatch repair, homologous recombination, mitotic recombination, double-strand break repair via single-strand annealing, and meiotic heteroduplex formation. It is also linked to the DNA damage checkpoint, DNA damage response, metaphase, anaphase, chromosome division, methylation, and gene conversion at the mating-type locus. The gene has been connected to decreased UV resistance, increased mutation frequency, decreased mitotic recombination, abnormal chromosome maintenance, decreased chronological lifespan, altered competitive fitness, and altered stress and chemical resistance.