SPT5 — Saccharomyces cerevisiae S288c

Summary

YML010W (SPT5) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a protein with RNA polymerase I general transcription initiation factor binding, RNA polymerase I core binding, snRNP binding, U5 snRNA binding, transcription elongation factor activity, U1 snRNA binding, U4 snRNA binding, U6 snRNA binding, ssRNA binding, U2 snRNA binding, RNAP II core binding, chromatin adaptor, rRNA binding, and histone binding activities. The protein contains NGN, KOW, and Spt5_C domains. SPT5 is associated with mRNA capping, RNA elongation from Pol II promoter, transcription pausing by RNA polymerase II, regulation of DNA-templated transcription elongation, mRNA processing, salivary gland development, positive regulation of RNA elongation from Pol I promoter, negative regulation of RNA elongation from Pol I promoter, regulation of transcription-coupled nucleotide-excision repair, gland development, mRNA transcription by RNA polymerase II, regulation of rRNA processing, upregulation of DNA repair, positive regulation of autophagy, intracellular mRNA localization, spliceosomal complex assembly, transcription by RNA polymerase I, and energy homeostasis. The gene product localizes to the nucleus, chromatin, rDNA heterochromatin, and ribosomes. Phenotypic associations include increased cold sensitivity, decreased vegetative growth, decreased competitive fitness, increased mutation frequency, decreased RNA accumulation, and inviability when disrupted. Related genes in other species are linked to the DSIF complex.