RAD52 — Saccharomyces cerevisiae S288c

Summary

YML032C, also known as RAD52 in Saccharomyces cerevisiae S288c, encodes a DNA-binding protein with recombinase activity, DNA reannealing activity, and damaged DNA binding capabilities. This protein localizes to the nucleus, chromatin, and sites of double-strand breaks, and is associated with homologous recombination, non-homologous end joining, recombinational repair, DNA breakdown, strand invasion, and replication fork arrest. The gene is linked to chromosome biorientation, sister chromatid cohesion establishment, and spindle assembly checkpoint. Phenotypic associations include decreased resistance to ionizing, gamma, and X-ray radiation, decreased meiotic and mitotic recombination, increased transposable element transposition, decreased viability, decreased sporulation, decreased fermentative and respiratory growth, decreased replicative lifespan, and increased innate thermotolerance. The gene is also associated with abnormal mitochondrial genome maintenance, nuclear morphology, and endoplasmic reticulum morphology.