ERG6 — Saccharomyces cerevisiae S288c

Summary

YML008C (ERG6) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a sterol 24C methyltransferase. The enzyme is associated with sterol and zymosterol metabolism, lipid storage and homeostasis, and mannan and glucan anabolism. ERG6 is linked to vacuole fusion, vesicle formation, exocytosis, protein targeting, plasma membrane polarization, spore germination, the pentose-phosphate shunt, and oxidative phosphorylation. The protein localises to the endoplasmic reticulum, mitochondria, plasma membrane, nucleus, and adiposomes. Associations with traits include oleic acid content, cell membrane stability, and sensitivities to salt, zinc, oxidative stress, light, and acid. Phenotypic connections include altered plasma membrane and actin cytoskeleton morphology, increased cell death and apoptosis, decreased spore germination, mating efficiency, and replicative lifespan, as well as increased cell size and filamentous growth. Studies of related genes in other species link the family to reduced virulence.