YPT7 — Saccharomyces cerevisiae S288c

Summary

YML001W (YPT7, RAB7) on chromosome XIII of Saccharomyces cerevisiae S288c encodes a small GTPase with GTP binding and GTPase activity. The gene is associated with vacuolar transport, vacuole fusion, vacuole inheritance, and vacuolar localization, as well as microautophagy, macropinocytosis, exocytosis, intracellular transport, and organelle localization. It is linked to nuclear movement, mitotic exit, and regulation of transport, including positive and negative regulation of non-autophagic vacuole fusion. The protein localizes to the vacuole, late endosome membrane, transport vesicle membrane, endomembrane system, and cellular bud tip. Associations include calcium, zinc, acid, light, and oxidative stress sensitivity, altered phosphate content, and phenotypes such as absent endocytosis and mitophagy, decreased autophagy, abnormal endomembrane system morphology, decreased replicative and chronological lifespan, increased innate thermotolerance, and altered stress, toxin, and metal resistance. Studies of related genes in other species link the family to loss of pathogenicity.