HMG2 — Saccharomyces cerevisiae S288c

Summary

YLR450W, also known as HMG1 or HMG2, encodes a protein with hydroxymethylglutaryl-CoA reductase (NADPH) activity and sterol sensor activity, and NADP binding, in Saccharomyces cerevisiae S288c on chromosome XII. It is a member of the HMG-CoA reductase catalytic and sterol-sensing domain families. The gene is associated with the mevalonate pathway and the biosynthesis of ergosterol, dolichol, and isoprenoids, as well as with cholesterol anabolism, CoA metabolism, and autophagic cell death. It has been linked to spore germination, response to wounding, endocytosis, membrane assembly, ER inheritance, and chromatin modeling. The product localizes to the ER and nuclear membranes, the peroxisome membrane, and the plasma membrane. Associations with traits include amino acid content, and phenotypes linked to the gene include altered ER and vacuolar morphology, lipid particle abnormalities, changes in sporulation efficiency, starvation resistance, metal and chemical resistance, and competitive fitness. Studies of related genes in other species connect the family to reduced virulence.