STE11 — Saccharomyces cerevisiae S288c

Summary

YLR362W in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with MEKK activity. The gene is associated with the MAPK cascade, pheromone response, pseudohyphal and invasive growth, protein phosphorylation, and protein kinase A signaling. It localizes to the division septum, cell tip, and plasmalemma. The gene is linked to traits including oleic acid content, hydrogen peroxide content, acid sensitivity, and oxidative stress. Phenotypic associations include absent mating response and shmoo formation, decreased osmotic stress resistance, increased pseudohyphal growth, and decreased invasive growth. Studies of related genes in other species link the family to MAP kinase kinase kinase activity (EC 2.7.11.25) and loss of pathogenicity.