CDC73 — Saccharomyces cerevisiae S288c

Summary

YLR418C in Saccharomyces cerevisiae S288c encodes a component of the Paf1 complex, a protein family member related to Cdc73/Parafibromin and containing the CDC73_C domain. The gene product is associated with RNA polymerase II core binding and positive regulation of transcription elongation by RNA polymerase II. It has been linked to numerous cellular processes including the MAPK cascade, PKC signal transduction, DNA damage response, homologous recombination, telomere maintenance, cell cycle modulation, chromatin modeling, rRNA processing, RNA breakdown and modification, methylation, and protein import into the mitochondrial intermembrane space. The protein localises to the nucleus, cytosol and Paf1 complex. YLR418C is associated with diverse phenotypes including decreased telomere length, increased mutation frequency, altered cell size, abnormal mitochondrial morphology and genome maintenance, increased transposable element transposition, altered stress resistance (including oxidative stress, heat, cold, acid, metal and light sensitivity), decreased respiratory and vegetative growth, and abnormal colony and bud morphology.