SEC61 — Saccharomyces cerevisiae S288c

Summary

YLR378C, also known as SEC61, encodes the alpha subunit of the Sec61 translocon complex in Saccharomyces cerevisiae S288c. The gene product possesses protein translocase activity, signal sequence binding, ribosome binding, and peptide transmembrane transporter activity. SEC61 is associated with SRP-dependent cotranslational membrane targeting and translocation, posttranslational protein membrane targeting and translocation, protein import, misfolded protein transport, and glycosylation. It localizes to the ER membrane, the plasma membrane, and extracellular vesicles. Phenotypic associations include inviability, increased cold and heat sensitivity, decreased vegetative growth rate, decreased competitive fitness, abnormal mitochondrial morphology, and altered resistance to chemicals. The gene is also linked to ergosterol anabolism, rhabdomere morphogenesis, and vision. Studies of related genes in other species place the Sec61 family within the conserved Sec61 translocon complex.