SEC13 — Saccharomyces cerevisiae S288c

Summary

YLR208W, also known as SEC13, encodes a structural protein of the WD40-repeat-containing Sec13/Seh1 family in Saccharomyces cerevisiae S288c on chromosome XII. The gene product is a component of the COPII vesicle coat and the SEA complex, and localizes to the ER membrane. SEC13 is associated with COPII-coated vesicle budding, vesicle formation, protein exit from the ER, and ER-to-Golgi transport. It is linked to nuclear envelope organization, nuclear pore localization, membrane tubulation, and cisternal maturation. The gene has been connected to the ERAD pathway, phospholipid anabolism, lipogenesis, lipid metabolism, morphogenesis, RNA transport, and positive regulation of TOR and TORC1 signaling. Phenotypic associations include decreased nutrient uptake and protein secretion, abnormal ER, nuclear, lipid particle, and mitochondrial morphology, decreased nucleolus size, increased heat sensitivity, altered chemical resistance, auxotrophy, and inviability.