VPS34 — Saccharomyces cerevisiae S288c

Summary

YLR240W (VPS34) in Saccharomyces cerevisiae S288c encodes a phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) with protein kinase activity and ATP binding. The gene is associated with phosphatidylinositol 3-phosphate biosynthesis, retrograde transport from the vacuole, vacuolar transport and fusion, vesicle tethering and formation, microautophagy, mitophagy, TORC1 assembly, polar cell growth, programmed cell death, response to nutrient, protein secretion, exocytosis, and glycolipid anabolism. The product localizes to the phosphatidylinositol 3-kinase complex class III types I and II, the nucleus-vacuole junction, trans-Golgi network membrane, pre-autophagosomal structure, endosome membrane, peroxisome, and fungal-type vacuole membrane. YLR240W is linked to calcium, zinc, light, acid, and oxidative stress sensitivity, altered potassium and phosphate content, and abnormal endocytosis, autophagy, protein transport, cell shape, budding pattern, and decreased viability, mating efficiency, and alkaline pH resistance. Studies of related genes in other species connect the family to phosphatidylinositol kinase activity and reduced virulence.