TOP3 — Saccharomyces cerevisiae S288c

Summary

YLR234W in Saccharomyces cerevisiae S288c encodes a type I topoisomerase with DNA-binding and metal-binding activities, belonging to the Topo_IA family. The gene product is localized to the nucleus and the RecQ helicase-Topo III complex, and is associated with DNA topological change, double-strand break repair, mitotic recombination, gene conversion, telomere maintenance, and the spindle and DNA damage checkpoints. It is also linked to the establishment of sister chromatid cohesion and maintenance of cell polarity. Phenotypic associations include increased mitotic recombination and mutation frequency, decreased telomere length, abnormal cell cycle progression and budding pattern, reduced growth rate, decreased resistance to hyperosmotic stress, desiccation, and metals, as well as absent respiratory growth and decreased competitive fitness.