TUB4 — Saccharomyces cerevisiae S288c

Summary

YLR212C in Saccharomyces cerevisiae S288c encodes gamma-tubulin, a structural constituent of the cytoskeleton with microtubule nucleator activity and GTP binding. The gene product localises to the spindle pole body plaques and gamma-tubulin complexes, and is associated with microtubule nucleation, spindle organisation and elongation, nuclear division, anaphase, mitotic checkpoint control, and meiotic spindle organisation. Phenotypic associations include cell cycle arrest in M phase, abnormal spindle morphology, increased cell size, decreased viability, heat sensitivity, reduced vegetative growth and competitive fitness, and altered chemical resistance. The gene is also linked to protein phosphorylation, positive regulation of cytoplasmic translation, and mitotic cytokinesis site selection. Studies of related genes in other species connect the family to similar microtubule-organising functions.