PDC5 — Saccharomyces cerevisiae S288c

Summary

YLR134W, also known as PDC5 and PDC1 on chromosome XII of Saccharomyces cerevisiae S288c, encodes a pyruvate decarboxylase that exhibits pyruvate decarboxylase activity, thiamine pyrophosphate binding, and magnesium binding. This enzyme is associated with glycolytic fermentation, alcohol anabolism, homofermentation, and the Ehrlich pathway for aromatic amino acid catabolism to alcohol. It is linked to vanillin and butanediol anabolism, D-xylose fermentation, glucose breakdown, and regulation of gluconeogenesis. The gene product is associated with respiration rate, biomass yield, and oxidative stress, as well as phenotypes including increased chronological lifespan, decreased heat sensitivity, altered competitive fitness, and abnormal vacuolar morphology. It localizes to the cytosol, plasma membrane, nucleus, yeast-form and hyphal cell walls, and the fungal biofilm matrix. Related genes in other species link the family to EC 4.1.1.1.