HOG1 — Saccharomyces cerevisiae S288c

Summary

YLR113W in Saccharomyces cerevisiae S288c encodes a protein with RNA polymerase II CTD heptapeptide repeat kinase activity, protein serine/threonine kinase activity, calmodulin binding, and chromatin binding, placing it in the MAP kinase family (MAPK_Sty1/Hog1, MAPK_p38-like). This gene is associated with diverse biological processes including response to cesium, arsenite transport, intracellular accumulation of glycerol, regulation of autophagy, mycose biosynthesis, ER stress response, osmotic response, flocculation, and downregulation of filamentous growth in response to heat. It localizes to the nucleus, cytoplasm, chromatin, and mitochondrial envelope lumen. Associations with traits include calcium sensitivity, salt tolerance, root number, glucose and oleic acid content, drought tolerance, potassium uptake, biomass yield, and oxidative stress. Phenotypic associations include decreased osmotic stress resistance, decreased viability, abnormal cell shape and budding pattern, increased cold sensitivity, and decreased mitophagy. Studies of related genes in other species link the family to reduced virulence.