MLH2 — Saccharomyces cerevisiae S288c

Summary

YLR035C, also known as MLH2, encodes a member of the MutL/Mlh/Pms-like protein family in Saccharomyces cerevisiae S288c. The product possesses ATP hydrolase activity, ATP binding, and mispair binding, and is annotated with ATP-dependent DNA damage sensor activity. This gene is associated with mismatch repair (MMR), regulation of mismatch repair, meiotic mismatch repair, and meiotic gene conversion. It is also associated with removal of nonhomologous ends, resolution of meiotic recombination intermediates, heteroduplex formation, maintenance of DNA repeat elements, replication fork arrest, and bypass DNA synthesis. Localization evidence places the product in the nucleus, nuclear chromosome, cytosol, and mitotic spindle pole body. Phenotypic associations include increased mutation frequency, altered cell cycle progression, abnormal vacuolar morphology, and altered resistance to chemicals. Studies of related genes in other species link the family to similar DNA repair processes.