SIC1 — Saccharomyces cerevisiae S288c

Summary

YLR079W (SIC1) on chromosome XII of Saccharomyces cerevisiae S288c is a cyclin-dependent kinase inhibitor. The gene is associated with the regulation of mitochondrial DNA replication, the mitotic cell cycle, protein phosphorylation, metaphase, spindle assembly, nuclear division, pseudohyphal growth, dephosphorylation, chromosome positioning, anaphase, glycan biosynthesis, morphogenesis, and telomere localization. It is linked to traits including protein content, oxidative stress, and acid sensitivity. Phenotypic associations include abnormal mitotic cell cycle, decreased entry into G0, increased starvation resistance, delayed G2/M phase transition, increased acid pH resistance, decreased G1 phase duration, decreased peroxisomal transport, increased budding index, increased telomere length, increased transposable element transposition, abnormal endoplasmic reticulum and nuclear morphology, decreased sporulation, decreased replicative lifespan, decreased innate thermotolerance, and absent respiratory growth.