SPA2 — Saccharomyces cerevisiae S288c

Summary

YLL021W, also known as SPA2 in Saccharomyces cerevisiae S288c, encodes a protein with MAP-kinase scaffold activity. This gene is associated with a wide range of biological processes, including mating behavior, chemotropism, bipolar bud site selection, karyogamy, cell differentiation, nuclear movement, polar cell growth, cell polarization, actin cytoskeleton organization, chitin anabolism, cell morphogenesis, protein secretion, the MAPK cascade, pheromone response, exocytosis, cytoskeleton organization, pseudohyphal growth, and DNA anabolism. The protein localizes to the CAR, the actomyosin contractile ring, the cell cortex of the growing cell tip, the mitotic actomyosin contractile ring, the division septum, the cell tip, and the cell division site. Phenotypic associations include absent cell fusion, abnormal shmoo formation, abnormal bipolar budding, decreased mating efficiency, absent filamentous and pseudohyphal growth, abnormal bud neck and cell morphology, and decreased chronological lifespan.