ASH1 — Saccharomyces cerevisiae S288c

Summary

YKL185W in Saccharomyces cerevisiae S288c encodes a DNA-binding transcription factor with a GATA-type zinc finger domain, localised to the nucleus. The gene is associated with the regulation of mating-type switching, the MAPK cascade, pseudohyphal and filamentous growth, macroautophagy, nuclear division, organelle inheritance, RNA localisation and transport, the glucose effect, and response to neutral pH. Phenotypic associations link YKL185W to increased mating-type switching, increased autophagy, decreased filamentous growth, decreased replicative lifespan, increased chronological lifespan, altered competitive fitness, and changes in resistance to acid, UV, metals and chemicals. Related genes in other species connect the family to mating-type regulation.