TRP3 — Saccharomyces cerevisiae S288c

Summary

YKL211C, also known as TRP3, on chromosome XI of Saccharomyces cerevisiae S288c, encodes a protein with phosphoribosylanthranilate isomerase, indole-3-glycerol-phosphate synthase, and anthranilate synthase activities. The gene product is a component of the anthranilate synthase complex and localizes to the cytosol. TRP3 is associated with tryptophan formation, amino acid anabolism, and the pentose-phosphate shunt, as well as with processes including transcription by RNA polymerase II, double-strand break repair, cytokinesis, and translation initiation. The gene has been linked to traits such as oleic acid content, salt sensitivity, and oxidative stress, and to phenotypes including auxotrophy, altered alkaline pH resistance, increased innate thermotolerance, and changes in vegetative growth rate, competitive fitness, and resistance to chemicals and toxins.