DNM1 — Saccharomyces cerevisiae S288c

Summary

YLL001W, also known as DNM1, on chromosome XII of Saccharomyces cerevisiae S288c, encodes a protein with membrane fusion GTPase activity, membrane scission GTPase motor activity, membrane bending activity, microtubule binding, lipid binding, GTPase activity, GTP binding, and metal binding. The gene is associated with mitochondrial and organelle fission, mitochondrial fusion, mitophagy, nucleophagy, macroautophagy, regulation of autophagy, organelle disassembly, apoptotic process, oxidative phosphorylation, mitochondrial biogenesis, reactive oxygen species anabolism, nuclear movement, and microtubule-mediated mitochondrion localization. It localizes to the mitochondrial outer and inner membranes, mitochondrial envelope lumen, microtubules, peroxisomes, fungal-type vacuole membrane, Golgi complex, cell division site, mitochondria, and plasmalemma. The gene is linked to oxidative stress, and phenotypes include altered mitophagy, apoptosis, viability, lifespan, respiratory growth, thermotolerance, desiccation resistance, toxin resistance, competitive fitness, and mitochondrial morphology.