TOR2 — Saccharomyces cerevisiae S288c

Summary

YKL203C (TOR2) on chromosome XI of Saccharomyces cerevisiae encodes a dual-specificity protein serine/threonine kinase with histone H2A kinase activity, pre-rRNA binding, and protein complex binding. It is a core component of the TOR complex and is associated with TORC2 signaling, TOR signaling, response to glucose and nutrients, positive regulation of DNA replication and cytoplasmic translation, sphingolipid anabolism, amino acid anabolism, RNA breakdown, G1 phase, and DNA damage response signal transduction. The gene is linked to numerous phenotypes including decreased osmotic stress resistance, increased heat sensitivity, altered alkaline pH resistance, changes in chronological and replicative lifespan, decreased fermentative metabolism, and altered vegetative growth and toxin resistance. Related genes in other species are associated with non-specific serine/threonine kinase activity.