YPK1 — Saccharomyces cerevisiae S288c

Summary

YKL126W in Saccharomyces cerevisiae S288c encodes a protein serine/threonine kinase with novel protein kinase C activity, ATP binding, and lipid binding capabilities. It contains a C2 domain and belongs to the AGC-kinase family. The gene is associated with TORC2 signaling, the sphingolipid-mediated signaling pathway, MAPK cascade, cell wall biogenesis, regulation of translation, iron transport, response to heat and lipid, pinocytosis, MOMP, septin checkpoint, and electron transport chain. It localizes to sites of polarized growth, the actomyosin contractile ring, division septum, stress granules, and the nuclear envelope. Phenotypic associations include increased alkaline pH resistance, decreased apoptosis, abnormal budding, decreased chitin deposition, increased biofilm formation, decreased replicative lifespan, and altered stress responses. Studies of related genes in other species link the family to reduced virulence.