RPT1 — Saccharomyces cerevisiae S288c

Summary

YKL145W (RPT1) on chromosome XI of Saccharomyces cerevisiae S288c encodes a proteasomal ATPase with ATP hydrolase activity and ATP binding capacity. The gene product is a component of the proteasome regulatory particle base subcomplex and is associated with 20S proteasome assembly, proteasomal protein catabolic processes, and the ERAD pathway. RPT1 is associated with cell cycle progression through the G2/M phase transition, vegetative growth, replicative lifespan, and oxidative stress and heat sensitivity. It is linked to chromatin, the nuclear periphery, and the cytoplasm, and is associated with processes including deubiquitination, DNA modification, and upregulation of RNA polymerase II transcriptional preinitiation complex assembly. Studies of related genes in other species link the family to similar proteasome functions.