YKL091C — Saccharomyces cerevisiae S288c

Summary

YKL091C, also known as SEC14, encodes a protein on chromosome XI of Saccharomyces cerevisiae S288c. The protein possesses phosphatidylcholine carrier activity, phosphatidylinositol carrier activity, and phosphoinositide binding, and belongs to the CRAL-TRIO domain family. SEC14 is associated with intracellular lipid transport, regulation of phospholipid metabolism, and both positive and negative regulation of phosphatidylcholine anabolism. It is linked to TOR signaling, regulation of receptor-mediated endocytosis, Golgi vesicle budding, and secretion. The protein localizes to the Golgi membrane, endosome, plasmalemma, cytoplasm, and cell tip. Phenotypic associations include increased mitotic recombination, abnormal sporulation, altered heat sensitivity, and changes in competitive fitness and chemical resistance. Studies of related genes in other species link the family to similar lipid transport functions.