HAP4 — Saccharomyces cerevisiae S288c

Summary

YKL109W, better known as HAP4 on chromosome XI of Saccharomyces cerevisiae S288c, encodes a protein that contains a Hap4_TF_heteromerisation domain. The gene is associated with a broad range of biological processes, including oxidative phosphorylation (OXPHOS), the tricarboxylic acid (TCA) cycle, gluconeogenesis, the retrograde response, and mitochondrial gene expression. It has also been linked to thiamin anabolism, sulfur metabolism, sterol import, TORC1 signaling, ribosome assembly, and responses to stress, starvation, nutrients, and carbohydrates. Phenotypic associations include altered respiratory and fermentative metabolism, changes in cell size, bud morphology, pseudohyphal and filamentous growth, sporulation efficiency, and lifespan. Additionally, HAP4 is associated with biomass yield, oxidative stress, and altered resistance to metals, UV, hyperosmotic stress, desiccation, and toxins.