HMS2 — Saccharomyces cerevisiae S288c

Summary

YJR147W in Saccharomyces cerevisiae S288c encodes a protein with phosphorelay response regulator activity and DNA-binding transcription activator activity specific to RNA polymerase II. The protein belongs to the HSF family and contains an HSF DNA-binding domain. It is associated with the MAPK cascade, protein kinase A signaling, pseudohyphal growth, invasive growth, filamentous growth, and the regulation of extracellular matrix assembly. The gene is linked to auxin anabolism, hypotonic response, response to anoxia and singlet oxygen, oxygen and glutathione metabolism, metabolic burst, histidyl-aspartyl phosphorelay, and regulation of the unfolded protein response. It localizes to the nucleus, cytosol, chromatin, and RNA polymerase II transcription regulator complex. Phenotypic associations include increased pseudohyphal and invasive growth, decreased chronological lifespan and metal resistance, increased competitive fitness and chemical resistance, and decreased vegetative growth rate. Studies of related genes in other species link the family to reduced virulence.