MSN4 — Saccharomyces cerevisiae S288c

Summary

YKL062W (MSN2) on chromosome XI of Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger transcription factor that binds cis-regulatory regions and exhibits RNA polymerase II-specific DNA-binding transcription factor activity. The gene is associated with responses to ethanol, heat, oxidative stress, and anoxia, as well as TOR signaling, the TCA cycle, glycerol anabolism, lipogenesis, and malate secretion. It is linked to traits including glucose content, light sensitivity, and calcium sensitivity, and to phenotypes such as increased osmotic stress resistance, increased chronological lifespan, increased respiratory growth, decreased fermentative metabolism, and altered stress resistance. The MSN2 protein localizes to the nucleus, cytoplasm, cytosol, and chromatin. Studies of related genes in other species link the family to reduced virulence.