TDH2 — Saccharomyces cerevisiae S288c

Summary

YJR009C in Saccharomyces cerevisiae S288c encodes a glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) with NAD and NADP binding activity. The gene is associated with glycolysis, mixed acid fermentation, D-galacturonate and valine metabolism, glycerolipid anabolism, the glycerophosphate shuttle, and isobutanol and isoprenoid anabolism. It is also linked to regulation of carbohydrate metabolism, protein palmitoylation, plasmid recombination, and response to methylglyoxal. The encoded protein localises to the cytosol, extracellular space, and the fungal biofilm matrix. Associations with traits such as biomass yield, protein content, and oxidative stress, as well as phenotypes including increased biofilm formation, altered replicative lifespan, and changes in heat and chemical sensitivity, further connect this gene to growth, stress tolerance, and cellular maintenance.