CYC1 — Saccharomyces cerevisiae S288c

Summary

YJR048W in Saccharomyces cerevisiae S288c encodes a protein with electron transfer activity and heme binding, belonging to the cytochrome c family (Cyt_c_1A/1B and Cyt_c-like domains). It is associated with mitochondrial electron transport, including both ubiquinol-to-cytochrome c and cytochrome c-to-oxygen steps, as well as heme transport, iron transport, and acyl-CoA metabolism. The protein localizes to the mitochondria and mitochondrial envelope lumen. Phenotypic associations link YJR048W to respiratory metabolism, with decreased respiratory growth and rate, increased replicative lifespan, altered stress responses including increased metal resistance and decreased desiccation resistance, and effects on filamentous growth, carbon and nitrogen source utilization, and competitive fitness. Studies of related genes in other species connect the cytochrome c family to mitochondrial electron transport and oxidative stress responses.