TOR1 — Saccharomyces cerevisiae S288c

Summary

YJR066W in Saccharomyces cerevisiae S288c encodes a dual-specificity protein kinase with histone H2A kinase activity, pre-rRNA binding, and protein complex binding capabilities. The gene is associated with TORC1 and TORC2 signaling, intracellular signal transduction, response to nutrients, glucose, and rapamycin, as well as mitophagy, mitotic recombination, and regulation of growth. It is linked to cellular amino acid homeostasis, glutamine, glycerol, and NAD anabolism, the pentose-phosphate shunt, and the TCA cycle. The encoded protein localizes to TOR complexes, nucleolar chromatin, and telomeric chromosome regions. Associations with traits include biomass yield, amino acid content, and oxidative stress. Phenotypic associations include increased stress resistance, altered lifespan, and changes in viability, apoptosis, and mitotic recombination. Studies of related genes in other species link the family to protein serine/threonine kinase activity.