SET2 — Saccharomyces cerevisiae S288c

Summary

YJL168C (SET2) in Saccharomyces cerevisiae S288c encodes a protein with histone H3K36 dimethylase, trimethylase, and methylase activities, as well as methyltransferase and RNA-binding functions. The protein localises to the chromosome, chromatin, cytosol, and nucleus. It is associated with DNA-templated transcription elongation, telomeric silencing, suppression of meiotic recombination, nucleotide excision repair (NER, TC-NER), base excision repair (BER), replicative and cellular senescence, and responses to xenobiotic stimuli. Associations include oxidative stress, acid sensitivity, and altered stress resistance. Phenotypic links encompass increased meiotic recombination and silencing, decreased UV and X-ray resistance, altered telomere length, sporulation efficiency, chronological lifespan, competitive fitness, and vacuolar morphology. The gene belongs to the SETD2/Set2_SET and SRI domain families.