SWE1 — Saccharomyces cerevisiae S288c

Summary

YJL187C in Saccharomyces cerevisiae S288c encodes a protein with annotated protein serine/threonine kinase activity, non-membrane spanning protein tyrosine kinase activity, MAPKK activity, and cAMP-dependent protein kinase activity, and it binds ATP and microtubules. The gene is associated with negative regulation of the G2/M transition of the meiotic cell cycle, mitotic spindle elongation, actin depolymerization, pseudohyphal growth, and the intrinsic apoptotic pathway. It localizes to the mitotic spindle pole body, division septum, and cAMP-dependent protein kinase complex. Phenotypic associations include premature and arrested G2/M phase progression, decreased cell size, abnormal bud morphology and spindle pole body position, increased invasive growth, and altered stress resistance. Studies of related genes in other species link the family to oxidative stress and protein content traits.