TPK1 — Saccharomyces cerevisiae S288c

Summary

YJL164C (TPK3) in Saccharomyces cerevisiae S288c encodes a protein with protein serine/threonine kinase activity, cAMP-dependent protein kinase activity, ribosomal protein S6 kinase activity, and lipid-binding properties. It is associated with diverse biological processes including TORC1 signaling, response to glucose, DNA damage checkpoint, non-homologous end joining, ascus development, regulation of sporulation, and regulation of response to osmotic stress. The gene product localizes to the cAMP-dependent protein kinase complex, nucleoplasm, actomyosin contractile ring, division septum, and fungal-type vacuole membrane. Phenotypic associations link YJL164C to decreased viability, reduced chronological lifespan, abnormal cell cycle progression, altered stress resistance (including increased osmotic stress resistance and decreased desiccation resistance), decreased vegetative growth, and abnormal actin cytoskeleton morphology. The gene is also associated with potassium concentration and oxidative stress traits.