PBS2 — Saccharomyces cerevisiae S288c

Summary

YJL128C, also known as PBS2, on chromosome X of Saccharomyces cerevisiae S288c encodes a protein with MAPKK activity, protein tyrosine kinase activity, and protein serine/threonine kinase activity. The gene is associated with the MAPK cascade, osmotic response, pheromone response, cell cycle control, mitophagy, macroautophagy, and regulation of ascospore formation. It is linked to mRNA transcription, cellular homeostasis, glucan, chitin, and sphingolipid anabolism, and protein kinase A signaling. Localization includes the cytoplasm, nucleus, division septum, and cell tip. Associations with traits include salt tolerance, calcium sensitivity, protein content, and oxidative, light, and acid sensitivity. Phenotypic associations include decreased osmotic stress resistance, decreased invasive growth, abnormal cell shape and budding pattern, and altered killer toxin resistance. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.