ARP4 — Saccharomyces cerevisiae S288c

Summary

YJL081C, also known as ARP4, on chromosome X of Saccharomyces cerevisiae S288c, encodes an actin-related protein that binds histones, chromatin, and ATP. The protein is a component of several chromatin-modifying complexes, including the SWI-SNF, INO80, SWR-C, and TIP60 complexes, and localises to the nucleus. ARP4 is associated with a broad range of nuclear processes, including chromatin organisation and remodelling, kinetochore assembly, DNA replication and repair, double-strand break repair, chromosome condensation, and cell cycle progression. The gene has been linked to traits such as oxidative stress, cold and heat sensitivity, hyperosmotic stress resistance, and toxin resistance. Phenotypic associations include decreased viability, colony size, vegetative growth, competitive fitness, and replicative lifespan, as well as abnormal nuclear and spindle morphology, and increased innate thermotolerance. Studies of related genes in other species link the family to similar actin-related functions.