DPB11 — Saccharomyces cerevisiae S288c

Summary

YJL090C in Saccharomyces cerevisiae S288c encodes a protein with signaling adaptor activity. The gene is associated with DNA replication elongation and initiation, the DNA replication checkpoint, homologous recombination, and non-photoreactive DNA repair. It is also linked to mating-type switching, meiotic heteroduplex formation, and the G2 and S phases of the cell cycle, as well as abscission and pre-RC assembly. The protein localizes to the nucleus, chromatin, the mitotic spindle and spindle pole body, the pre-initiation complex, and sites of double-strand breaks. Phenotypic associations include abnormal mitotic recombination, decreased mating-type switching, S-phase arrest or delay, decreased chromosome/plasmid maintenance, increased invasive growth, heat sensitivity, and altered chemical resistance. The gene is also connected to oxidative stress. Related genes in other species link the family to DNA damage responses.