SRS2 — Saccharomyces cerevisiae S288c

Summary

YJL092W encodes a protein with 3'-5' DNA helicase activity, ATP hydrolase activity, and DNA binding, and belongs to the UvrD-like DNA helicase family. It is localized to the nucleus and is associated with meiosis I and II, prophase, anaphase, DNA metabolism, postreplication repair, nucleotide excision repair, gene conversion, telomere maintenance, sister chromatid cohesion, regulation of non-homologous end joining, DNA recombinase assembly, sumoylation, the mitotic cell cycle, and the DNA damage checkpoint. The gene is linked to decreased resistance to ionizing, X-ray, and gamma radiation, increased UV resistance, decreased oxidative stress resistance, increased heat sensitivity, increased mutation frequency, decreased replicative and chronological lifespan, increased invasive growth, and abnormal chromosome maintenance. Studies of related genes in other species link the family to DNA helicase activity (EC 5.6.2.4).