KAR2 — Saccharomyces cerevisiae S288c

Summary

YJL034W, also known as KAR2 or BiP1 in Saccharomyces cerevisiae S288c, encodes an ATP-dependent protein folding chaperone with protein translocase activity, heat shock protein binding, and unfolded protein binding functions. It is localized to the endoplasmic reticulum lumen and nuclear membrane. The gene is associated with nuclear membrane fusion, karyogamy, ER membrane fusion, protein secretion, protein folding, the IRE1 branch of the unfolded protein response, ER stress-induced apoptosis, invasive growth, and fungal-type cell wall beta-glucan biosynthesis. Phenotypic associations include absent or abnormal nuclear fusion during mating, decreased innate thermotolerance, increased heat sensitivity, increased oxidative stress resistance, decreased chronological lifespan, abnormal cell shape and morphology, decreased vegetative growth rate, and altered resistance to chemicals.