SMC3 — Saccharomyces cerevisiae S288c

Summary

YJL074C (SMC3) in Saccharomyces cerevisiae S288c encodes a structural maintenance of chromosomes (SMC) family protein with DNA translocase, ATP hydrolase, and chromatin-binding activities. It is a core component of the cohesin and condensin complexes, localising to chromosomes, centromeres, and kinetochores. The gene is associated with sister chromatid cohesion, chromosome condensation, chromatin looping, centromere separation, and mitotic and meiotic chromosome segregation. It has been linked to cell cycle progression through prophase, metaphase, anaphase, and cytokinesis, as well as to meiotic recombination, sporulation, and apoptosis. Phenotypic associations include abnormal chromosome segregation, inviability, haploid insufficiency, decreased competitive fitness, increased heat sensitivity, altered oxidative stress resistance, and changes in toxin and chemical resistance.