TDH1 — Saccharomyces cerevisiae S288c

Summary

YJL052W encodes a glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) with NAD and NADP binding activity in Saccharomyces cerevisiae S288c. The gene is associated with diverse metabolic processes including mixed acid fermentation, D-galacturonate and valine metabolism, the glycerophosphate shuttle, and isobutanol anabolism. It is linked to responses to methylglyoxal, cisplatin, and oxidative stress, as well as regulation of localization and self-proteolysis. The protein localizes to the cytosol, extracellular space, and fungal biofilm matrix. Associations with biomass yield, protein content, salt tolerance, and oxidative stress have been noted. Phenotypic connections include decreased viability, biofilm formation, and chronological lifespan, alongside increased innate thermotolerance and altered competitive fitness. Studies of related genes in other species further link the family to general stress responses and metabolic regulation.