FKH1 — Saccharomyces cerevisiae S288c

Summary

YIL131C, also known as FKH1, encodes a forkhead family transcription factor on chromosome IX of Saccharomyces cerevisiae S288c. The protein contains a forkhead domain and a FHA domain, and has been annotated with DNA-binding transcription factor activity, including both activator and repressor functions specific to RNA polymerase II. FKH1 is associated with cell cycle regulation, including the G2/M phase transition, anaphase, and the switch between mitotic and meiotic cycles. It is linked to mating type switching, pseudohyphal growth, ribosome biogenesis, and nucleoside metabolism. The gene is connected to numerous phenotypes, including decreased resistance to oxidative stress, UV, acid pH, and heat, as well as increased chronological lifespan and altered cell cycle progression. FKH1 localises to the nucleus and chromatin. Studies of related genes in other species link the family to loss of pathogenicity.