YIL144W — Saccharomyces cerevisiae S288c

Summary

YIL144W in Saccharomyces cerevisiae S288c encodes a component of the Ndc80 kinetochore complex, a member of the NDC80 superfamily and DUF5595 domain family. The protein binds microtubules and identical proteins, and is localized to the Ndc80 complex, centromere complex, and nucleus. It is associated with spindle pole body separation, kinetochore assembly, spindle assembly checkpoint, chromosome biorientation, spindle elongation, and microtubule dynamics. The gene is linked to cell cycle progression in anaphase and M phase, chromosome segregation, spindle morphology, nuclear morphology, and telomere length. It is associated with response to glucose, protein kinase A signaling, sumoylation, and oxidative stress. Phenotypic associations include increased cold and heat sensitivity, decreased toxin resistance, increased cell size, abnormal budding index, and decreased vegetative growth. Studies of related genes in other species link it to similar kinetochore functions.