BCY1 — Saccharomyces cerevisiae S288c

Summary

YIL033C (BCY1) on chromosome IX of Saccharomyces cerevisiae S288c encodes a protein with cAMP-dependent protein kinase regulator activity, PKA catalytic subunit binding, cAMP-dependent protein kinase inhibitor activity, cAMP binding, and identical protein binding. BCY1 is associated with glucose response, cAMP metabolism, regulation of adenylyl cyclase activity, downregulation of Ras signal transduction, G1 phase and G1/G0 transition, autolysis, glycogen anabolism, double-strand break repair, stringent response, and protein localization to the bud neck. The gene is linked to decreased fermentative, respiratory, and vegetative growth, abnormal chromosome segregation and mitochondrial morphology, reduced spore germination, absent sporulation and carbon source utilization, decreased osmotic stress, starvation, desiccation, oxidative stress, and heat resistance, and altered protein accumulation and modification. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.