SKN7 — Saccharomyces cerevisiae S288c

Summary

YHR206W in Saccharomyces cerevisiae S288c encodes a protein with histidine kinase activity, phosphorelay sensor kinase and response regulator activities, and DNA-binding transcription activator activity specific to RNA polymerase II. This product is associated with osmotic response, oxidative stress response, MAPK cascade, invasive growth, protein ubiquitination, auxin anabolism, mRNA breakdown, translation initiation, and regulation of the unfolded protein response. It localizes to the nucleus, cytoplasm, membrane, and chromatin. The gene is linked to decreased stress resistance, including hyperosmotic, oxidative, UV, heat, and desiccation sensitivity, as well as reduced vegetative growth, decreased filamentous growth, increased mutation frequency, abnormal cellular morphology, and decreased replicative lifespan. Related genes in other species connect this gene family to reduced virulence.