HFD1 — Neurospora crassa

Summary

NCU04013 (symbol HFD1, also known as ylo-1) on Neurospora crassa chromosome 6 encodes an aldehyde dehydrogenase family protein with NAD(P)+-dependent 4-hydroxybenzaldehyde dehydrogenase, succinate-semialdehyde dehydrogenase, betaine-aldehyde dehydrogenase and carboxylate reductase activities (EC 1.2.1.82). The gene is associated with aldehyde, acetaldehyde, polyamine and GABA catabolism, as well as carotenoid and ubiquinone biosynthesis, pigmentation, sphingolipid metabolism, ethanol metabolism, acetate biosynthesis, carbon catabolite activation of transcription, response to amino acid starvation and actidione, and cellular detoxification of nitrogen compounds. The product localises to mitochondria, the mitochondrial outer membrane, cytoplasm, cytosol, nucleus, membrane, extracellular region and adiposomes. Associations with decreased mitochondrial transport, absent respiratory metabolism, altered cell death, decreased gamma ray and ionic stress resistance, abnormal vegetative growth, increased biofilm formation, decreased alkaline pH resistance, and altered protein secretion and autophagy have been noted. Studies of related genes in other species link the family to transposable element transposition.