CPCA — Neurospora crassa

Summary

NCU04050 (CPCA, cpc-1) on Neurospora crassa chromosome 6 encodes a bZIP transcription factor with DNA-binding and RNA polymerase II cis-regulatory region sequence-specific DNA-binding activity. The gene is associated with response to amino acid starvation and histidine, circadian rhythm, glycogen metabolism, nitrogen catabolite activation of transcription, protein stabilization, spore germination, and regulation of gene expression. It is also linked to nonsense-mediated mRNA decay, translation elongation and initiation, protein folding and breakdown, and digestion. The product localizes to the nucleus and transcription regulator complex. Studies of related genes in other species link the family to reduced virulence, though this has not been established in N. crassa.