AHA1 — Neurospora crassa

Summary

NCU04087 (AHA1) in Neurospora crassa encodes an Aha1 domain-containing protein with ATPase activator activity and chaperone protein binding. It is associated with protein folding and hypersensitivity, and localises to both the cytosol and nucleus. The gene has been linked to numerous phenotypes, including increased thermotolerance, altered cell cycle progression (notably G2/M phase transition and M phase duration), abnormal chromosome segregation, decreased radiation resistance, increased meiotic recombination, and changes in mitochondrial transport and genome maintenance. It also shows connections to vegetative growth arrest, decreased spore germination, and abnormal nuclear import and position. Studies of related genes in other species link the AHA1 family to reduced virulence.